7.5 Why NIPT Is Still Important After PGT-A – A Guide for Surrogate Mothers and Intended Parents

NIPT (Non-Invasive Prenatal Testing) is a blood test performed around 9–10 weeks of pregnancy to screen for chromosomal abnormalities such as Down syndrome. Even if an embryo has passed PGT-A screening during IVF, NIPT is still recommended to confirm fetal health. For surrogate mothers, it’s essential to coordinate early with their doctor and surrogacy agency to ensure the test is done on time, avoiding delays and providing peace of mind for intended parents.

What Is NIPT?

Non-Invasive Prenatal Testing (NIPT) is a safe and simple blood test offered during early pregnancy. It analyzes small fragments of fetal DNA in the mother’s bloodstream to screen for common chromosomal abnormalities, including:

• Trisomy 21 (Down syndrome)
• Trisomy 18 (Edwards syndrome)
• Trisomy 13 (Patau syndrome)
• Sex chromosome abnormalities (such as Turner syndrome or Klinefelter syndrome)

As a leading surrogacy agency, GSHC Surrogacy & Egg Donation ensures all surrogate mothers are informed about prenatal testing expectations. NIPT is considered a highly accurate screening tool but is not diagnostic—abnormal results should be confirmed through follow-up testing.

If the Embryo Passed PGT-A, Do You Still Need NIPT?

Yes. Even if a PGT-A-tested euploid embryo was transferred, NIPT is still necessary. PGT-A (Preimplantation Genetic Testing for Aneuploidy) screens embryos before transfer, but:

• It only tests a few cells from the embryo’s outer layer.
• It may not detect mosaicism or other genetic anomalies.
• NIPT offers an added layer of reassurance during pregnancy.

At GSHC, we educate our surrogate mothers and intended parents that both PGT-A and NIPT play important roles in ensuring a healthy outcome. Major reproductive health organizations continue to recommend NIPT for all pregnancies—including those via IVF and surrogacy.

When Should NIPT Be Performed?

The optimal window for NIPT is between 9 and 10 weeks of gestation, when there is enough fetal DNA in the mother’s bloodstream for accurate analysis. The test is conducted through a simple blood draw, and results typically take up to 2 weeks.

GSHC case managers work closely with surrogate mothers to help coordinate this step and ensure timely communication with clinics and intended parents.

Important Guidance for Surrogate Mothers: Timing Matters

As a trusted surrogacy agency, GSHC has observed that many surrogate mothers feel unsure about the NIPT process, especially after a PGT-A-tested embryo transfer. Here's what every surrogate should know:

• Speak with your OB during your first prenatal visit to confirm when NIPT should be scheduled.
• Ensure the test is performed during the first trimester—ideally between 9 and 10 weeks.
• Stay in touch with your doctor and your GSHC case manager to confirm the test is completed on time.
• Remember that results can take up to 2 weeks, so schedule early to prevent delays in the journey.

Early and clear coordination ensures a smooth experience and helps provide confidence for both the surrogate and the intended parents.

At GSHC Surrogacy & Egg Donation, we are committed to supporting our surrogate mothers through every step of the journey—medical, emotional, and logistical. If you are a surrogate or an intended parent with questions about NIPT or prenatal care, our experienced team is here to guide you.